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KMID : 0366219860210010133
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Korean Journal of Hematology
1986 Volume.21 No. 1 p.133 ~ p.139
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Diphenylhydantoin-Induced Agranolocytosis with Atypical Bone Marrow findings
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조현찬(趙顯燦)/Hyoun Chan Cho
조영숙(趙英淑)/박정현(朴正賢)/이규만(李揆晩)/이영천(李榮天)/이영(李瀛)/Young Sook Cho/Joung Hyoun Park/Kyu Man Lee/Young Chun Lee/Young Lee
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Abstract
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Many drugs in the treatment of disease may induce serious damage to the hemopoietic
system. Agranulocytosis or selective loss of polymorptonuclear leukocytes is a term
reserved for a reasonably well-defined syndrome characterized by severe infection with
marked peripheral neutropenia and believed to be of drug-induced origin. Despite
widespread use since 1938, reports of severe granulocytopenia associated with DPH have
been uncommon. Bone marrow morphology, when described, has been characterized as
showing "maturation arrest", with normal erythroid precursors and megakaryocytes, but
wilt degeneration of myeloid cells. Recently we encountered a patient with clinical
syndrome of granulocytopenia associated with diphenylhydantoin therapy, which is
characterized by transient eosinophilia in recovery phase and an aggregate of azurophilic
granules around Golgi apparatus. These peculiar findings were not described in previous
reports. And also using liquid culture system on hemopoietic cells, we noted normal
differentiation of immature myeloid cells and disappearance of the peculiar granular
pattern of these cells.
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KEYWORD
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